The Insigneo Institute for in silico Medicine is an initiative between the University of Sheffield’s Faculty of Engineering, its Faculty of Medicine, Dentistry & Health, and the Sheffield Teaching Hospitals NHS Foundation Trust. The Institute develops computational models of the human physiology, which are capable of predicting the personal health status of every individual. These models can be used for the personalised prevention, diagnosis and treatment of diseases. The processes developed in Insigneo will fundamentally transform the future of the healthcare system and contribute to its long-term sustainability. Pursuing the scientific ambition behind the Virtual Physiological Human initiative, Insigneo was launched in May 2012 and attracted over 130 academics and clinicians to collaborate on in silico medicine projects. Insigneo work in partnership with Sheffield Robotics to jointly run the movement and perception analysis lab.